Differential MicroRNA Expression Profiles in Peripheral Arterial Disease

Differential microRNA expression profiles in peripheral arterial disease.

BACKGROUND Peripheral arterial disease (PAD) is a clinical condition caused by an atherosclerotic process affecting the arteries of the limbs. Despite major improvements in surgical endovascular techniques, PAD is still associated with high mortality and morbidity. Recently, microRNAs (miRNAs), a class of short noncoding RNA controlling gene expression, have emerged as major regulators of multi...

Differential Microrna Expression Profiles in Peripheral Arterial Disease Editorial See P 441 Clinical Perspective on P 497 Differential Microrna Expression Profiles in Peripheral Arterial Disease Materials and Methods Sample Collection Mirna and Mrna Expression Profiling

Philip W. Stather, Nicolas Sylvius, John B. Wild, Edward Choke, Robert D. Sayers and Differential MicroRNA Expression Profiles in Peripheral Arterial Disease Print ISSN: 1942-325X. Online ISSN: 1942-3268 Copyright © 2013 American Heart Association, Inc. All rights reserved. Dallas, TX 75231 is published by the American Heart Association, 7272 Greenville Avenue, Circulation: Cardiovascular Genet...

Circulating microRNA profiles for detection of peripheral arterial disease: small new biomarkers for cardiovascular disease.

Prevalence of Peripheral Arterial Disease in Diabetic Patients

Objective: Peripheral Arterial Disease (PAD) is a state characterized by atherosclerotic occlusive disease of lower extremities. Diabetes is the main risk factor for PAD. Material and Methods: To assess the prevalence of PAD, a cross sectional study was performed on 352 diabetic patients who referred to Yazd diabetes research center from 2007 to 2010. Vascular assessment was done by measuring ...

Negative Regulation of Semaphorin-3A Expression in Peripheral Blood Mononuclear Cells Using MicroRNA-497-5p

Background: Semaphorin-3A (Sema3A), as a secreted semaphorin, is an immune modulator molecule participating in the pathogenesis of autoimmune diseases. MicroRNAs (miRNAs) modulate the target-gene expression at the post-transcriptional level. It has been proposed that miRNAs may be crucial to the modulation of the function of semaphorins. Previous findings have proven that miR-497-5p is upregula...